demographic and prognostic factors of 455 patients with acute leukemia admitted to two referral hospitals in tehran-iran during ten years (2001-2011)
نویسندگان
چکیده
background: global death toll of acute leukemia (al), as a heterogeneous group of hematopoietic malignancies, is rather high, i.e. almost 74% of 300,000 new cases die every year. this reflects a poor prognosis of this malignancy in most parts of the world, where contemporary and rather complex remedies are not available. there are a few well documented reports about the epidemiologic features of al at national level in iran. this retrospective study demonstrates demographic and laboratory features of acute myeloid leukemia (aml) and acute lymphoblastic leukemia (all) patients admitted to the main referral oncology hospitals in the ex-iran university of medical sciences in tehran (firoozgar and rasoul-akram hospitals) during the last decade (2001-2011). methods: medical records of all patients admitted to the both hospitals diagnosed with aml and all were reviewed during the study period for demographic, biological and clinical characteristics at diagnosis. results: four-hundred fifty five patients were diagnosed with aml and all, who admitted to the both hospitals during ten years, of whom 59.6 % (271 patients) were male. fifty five percent of patients had aml and 44.6 % had all, both significantly dominated in men (p<0.001). aml patients died more significantly (p<0.05) and the most deaths occurred in older patients (p<0.001). initial wbc count was significantly related to death (p= 0.001), where the least death (13%) occurred in the group with initial wbc between 5-10×10 3 /μl and most of deceased had an initial wbc more than 10×10 3 /μl. logistic regression showed that age, fever and wbc were significant prognostic factors. conclusion: demographic characteristics of al patients were almost the same as other global reports. most deaths occurred in older patients, those who had fever, and patients with higher wbc count at first admission, which warrants more investigations accurately and also improvements in hospital records.
منابع مشابه
Demographic and Prognostic Factors of 455 Patients with Acute Leukemia Admitted to Two Referral Hospitals in Tehran-Iran During Ten Years (2001-2011)
BACKGROUND Global death toll of Acute Leukemia (AL), as a heterogeneous group of hematopoietic malignancies, is rather high, i.e. almost 74% of 300,000 new cases die every year. This reflects a poor prognosis of this malignancy in most parts of the world, where contemporary and rather complex remedies are not available. There are a few well documented reports about the epidemiologic features of...
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Acute renal failure (ARF) is defined as a sudden and continuous decrease of glomerular function associated with azotemia, and may be followed by decreased urinary output. There is a high incidence of ARF in ICU patients with a high mortality rate. Many factors can promote ARF development or influence its outcome. This study was done to assess the incidence, risk factors, outcome and treatme...
متن کاملExpression of BCL2L12 in acute leukemia patients: Potential association with clinical and prognostic factors
Introduction: Apoptosis is an important mechanism in both physiological and pathological conditions. The BCL2 family of proteins plays a critical role in regulation of apoptotic cell death. Up and down regulation of BCL2-like 12 (BCL2L12), a new member of the BCL2 family, has been reported in several malignancies. However, the expression level of BCL2L12 rarely has been studied in leukemia. T...
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متن کاملCauses of Persistently Elevated Alanine Aminotransferase Levels in Patients who Presented to Two Referral Hospitals in Mashhad, Iran during 2011
BACKGROUND Worldwide, chronic liver disease is a major cause of morbidity and mortality. Causes of elevated serum alanine aminotransferase (ALT) levels vary depending on the population under study. The aim of this study is to evaluate the frequency and causes of persistently elevated ALT levels in patients of the Gastroenterology (GI) Clinics in Ghaem and Emam Reza Hospitals in Mashhad, Iran. M...
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عنوان ژورنال:
iranian journal of cancer preventionجلد ۵، شماره ۳، صفحات ۱۵۷-۱۶۳
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